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Lymphocytic hypophysitis. Case report

R G Naik1, A Ammini, P Shah

  • 1Department of Endocrinology, All India Institute of Medical Sciences, New Delhi.

Journal of Neurosurgery
|May 1, 1994
PubMed
Summary
This summary is machine-generated.

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This case study details lymphocytic hypophysitis, a rare pituitary inflammation, presenting with panhypopituitarism eight years post-childbirth. It highlights a prolonged latent period and persistent pituitary enlargement in this condition.

Area of Science:

  • Endocrinology
  • Neurology
  • Pathology

Background:

  • Lymphocytic hypophysitis (LH) is an uncommon inflammatory condition affecting the pituitary gland, often presenting during pregnancy or postpartum.
  • It can lead to hypopituitarism and symptoms related to pituitary mass effect.
  • The diagnosis is typically confirmed by histology, often after surgery for a presumed pituitary adenoma.

Observation:

  • A patient presented with panhypopituitarism eight years after her last childbirth.
  • Initial symptoms of headache, vomiting, and diplopia occurred seven months postpartum, resolving with treatment.
  • Later development of hypoadrenalism, hypothyroidism, and amenorrhea prompted investigation, revealing a pituitary mass lesion.

Findings:

  • Histological examination confirmed lymphocytic hypophysitis despite a provisional diagnosis of pituitary adenoma.

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  • The case demonstrates an unusually long latent period of eight years between initial symptoms and the development of panhypopituitarism.
  • Pituitary gland enlargement persisted for many years, a feature not previously reported in such a long-term context.

    • Implications:

    • This case underscores the importance of considering lymphocytic hypophysitis in the differential diagnosis of pituitary dysfunction, even with delayed presentation.
    • The findings suggest that pituitary enlargement in LH can be a long-standing feature, potentially mimicking other pituitary pathologies.
    • Further research into the long-term natural history and management of lymphocytic hypophysitis is warranted.