[Tissue immunity reactions in experimental aspergillosis]

The authors have developed a model of acute and chronic aspergillosis induced by Aspergillus fungi injected intraperitoneally to white mice. Subsequent histological evaluation of the mouse viscera identified 3 phases of tissue immunity reactions: non-specific, characterized by mucosal epithelial proliferation and hypersecretion, lymphoid reaction and development of diffuse alveolitis in the lungs, rapid growth of aspergilla; specific, characterized by pronounced proliferative processes, onset of lymphoid-histiocytic and macrophagal pneumonia, emergence of small thin-wall intraalveolar micetomas, absence of aspergilla growth from homogenates of the internal organs; productive, characterized by formation of granuloma, large aspergillomas in the liver and mesenterium. The course of experimental aspergillosis reflects the process of immunity formation in response to advancing infection.