[Evaluation of immunologic response in individuals of various ages to Td vaccine]

Forty adults volunteers 25-65 years received 10 BU tetanus and 2 Lf diphtheria adsorbed vaccine (Td). The tolerance was very good, it was not depended on the age antitoxin level. Eleven persons have not diphtheria immunity before the vaccination. The serological response was determined by the passive hemagglutination in sera collected in 4 week after the vaccination. Only in one serum the level of diphtheria antitoxin was below 0.1 IU/ml. It is recommended than two doses of Td vaccine are necessary for anyone whose last dose of diphtheria anatoxin was given more than 10 years ago especially to persons travelling to other countries at risk for diphtheria.