[Angiotensins in the mechanisms of drinking, feeding and alcohol motivations]

In the paper was described the influence of angiotensin-2, captopril, bestatin, and angiotensin-2-(3-7) fragment on drinking, feeding and alcohol directed behaviour. It was found that dipsogenic doses of angiotensin-2 could inhibit food and alcohol intake mostly by a suppression of food and alcohol motivations. Specific antagonist of "classical" angiotensin-2 receptors saralasin could not block angiotensin-2 effects. A significant decrease of food and ethanol intake was revealed after intraventricular injections of enzyme blockers captopril and bestatin, which increase endogenic levels of angiotensin-1 and angiotensin-3, and also angiotensin-2-(3-7). So was shown the ability of angiotensins to suppress the dominant food or alcohol motivations by the activation of some other but not the "classical" angiotensin-2 receptors. Was suggested the involvement of angiotensins in the coordination of the different kinds of functional systems to create the optimal conditions for realization of drinking behaviour.