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Related Experiment Videos

Moxidectin against ivermectin-resistant nematodes--a global view

P J Kieran1

  • 1Cyanamid International, Singapore.

Australian Veterinary Journal
|January 1, 1994
PubMed
Summary

Moxidectin, a potent macrocyclic lactone endectocide, effectively controls nematode strains resistant to ivermectin in sheep and goats. Strategic use of moxidectin can mitigate further development of anthelmintic resistance.

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Area of Science:

  • Veterinary Parasitology
  • Anthelmintic Resistance
  • Drug Discovery

Background:

  • Macrocyclic lactone endectocides, including moxidectin (milbemycin) and ivermectin (avermectin), are crucial for controlling nematode infections in livestock.
  • Nematode resistance to anthelmintics is a growing concern in sheep and goat farming, impacting treatment efficacy.
  • The chemical distinctions between moxidectin and ivermectin and their implications for resistance are not fully understood.

Purpose of the Study:

  • To evaluate the efficacy of moxidectin against ivermectin-resistant nematode strains in sheep and goats.
  • To compare the potency of moxidectin and ivermectin against key nematode genera involved in anthelmintic resistance.
  • To assess the role of moxidectin in strategic treatment programs for managing macrocyclic lactone endectocide resistance.

Main Methods:

  • Clinical studies involving sheep and goats infected with nematode strains.
  • Administration of moxidectin at a recommended dose rate (0.2 mg/kg).
  • Monitoring of nematode control and comparison with ivermectin efficacy.

Main Results:

  • Moxidectin demonstrated control over identified nematode strains resistant to ivermectin.
  • Moxidectin exhibited significantly greater potency against Haemonchus, Ostertagia, and Trichostrongylus, genera central to anthelmintic resistance.
  • The findings support moxidectin's effectiveness in overcoming existing resistance.

Conclusions:

  • Moxidectin is a valuable therapeutic option for managing ivermectin-resistant nematode populations in small ruminants.
  • Implementing moxidectin in strategic treatment programs may reduce the risk of developing further resistance to macrocyclic lactone endectocides.
  • Further research into the chemical basis of differential efficacy is warranted.

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