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Collectin receptor (C1q receptor): structure and function

R Malhotra1

  • 1MRC Immunochemistry Unit, Department of Biochemistry, Oxford, UK.

Behring Institute Mitteilungen
|December 1, 1993
PubMed
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This summary is machine-generated.

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The collectin receptor, a 60 kDa protein, binds to collectins like C1q and mannose binding protein (MBP). This receptor is found on immune cells and endothelium, playing a role in opsonization.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • The collectin receptor (C1q receptor) is a ~60 kDa polypeptide.
  • Sequence analysis indicates it belongs to a protein family including calreticulin and various antigens.
  • This receptor is expressed on leukocytes, platelets, and endothelium.

Purpose of the Study:

  • To characterize the isolated collectin receptor (C1q receptor).
  • To identify the protein family and distribution of the collectin receptor.
  • To define the function of the collectin receptor in binding collectin opsonins.

Main Methods:

  • Protein characterization via molecular weight estimation (~60 kDa).
  • Sequence analysis to determine protein family relationships.

Related Experiment Videos

  • Distribution studies on various cell types (leukocytes, platelets, endothelium).

    • Main Results:

    • The collectin receptor is a single polypeptide chain of approximately 60 kDa.
    • It shares sequence homology with calreticulin and other antigens.
    • The receptor is widely distributed and binds collectins such as C1q, MBP, SP-A, and conglutinin.

    Conclusions:

    • The collectin receptor is a distinct protein involved in the innate immune system.
    • Its widespread distribution suggests a significant role in host defense.
    • It acts as a crucial binding site for collectin-mediated opsonization.