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B cell antigen receptors

M Reth1

  • 1Max-Planck Institut für Immunbiologie, Freiburg, Germany.

Current Opinion in Immunology
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

B lymphocyte antigen receptors bind antigens and trigger cell activation. Researchers designed new receptors combining these functions into one molecule for improved B cell response.

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Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • B lymphocytes utilize antigen receptors for antigen binding, internalization, and B cell activation.
  • The antigen receptor comprises a ligand-binding immunoglobulin (Ig) molecule and a signal-transducing Ig-alpha/Ig-beta heterodimer.
  • Structural requirements for antigen internalization remain under investigation.

Purpose of the Study:

  • To investigate the functional division of B lymphocyte antigen receptors.
  • To design novel antigen receptors by integrating ligand-binding and signal-transducing functions into a single molecular entity.

Main Methods:

  • Analysis of the structural and functional components of B lymphocyte antigen receptors.
  • Design and engineering of variant antigen receptors.

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Main Results:

  • The antigen receptor is functionally divided into an Ig molecule for ligand binding and an Ig-alpha/Ig-beta heterodimer for signal transduction.
  • Engineered variant antigen receptors successfully combined both antigen-binding and signal-transducing functions.

Conclusions:

  • The functional dichotomy of the B lymphocyte antigen receptor is confirmed.
  • The design of single-molecule antigen receptors offers a promising strategy for modulating B cell responses.