Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antigen presentation by non-classical class I molecules

I Stroynowski1, K F Lindahl

  • 1Gifford Laboratories for Diabetes Research, University of Texas Southwestern Medical Center, Dallas.

Current Opinion in Immunology
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Promiscuous antigen presentation by the nonclassical MHC Ib Qa-2 is enabled by a shallow, hydrophobic groove and self-stabilized peptide conformation.

Structure (London, England : 1993)·2001
Same author

Widespread expression of the nonclassical class I Qa-2 antigens in hemopoietic and nonhemopoietic cells.

Immunogenetics·2001
Same author

Characterization of clustered MHC-linked olfactory receptor genes in human and mouse.

Genome research·2001
Same author

G7c in the lung tumor susceptibility (Lts) region of the Mhc class III region encodes a von Willebrand factor type A domain protein.

Immunogenetics·2001
Same author

Memories of a mentor: Charley Steinberg.

Genetics·2001
Same author

Qa-2-dependent selection of CD8alpha/alpha T cell receptor alpha/beta(+) cells in murine intestinal intraepithelial lymphocytes.

The Journal of experimental medicine·2000
Same journal

The food additive microbial transglutaminase is a potential new environmental inducer of autoimmune diseases.

Current opinion in immunology·2026
Same journal

Mapping the synovial immune ecosystem in rheumatoid arthritis: cellular cartography and pathotype-guided immune restoration.

Current opinion in immunology·2026
Same journal

Noncanonical ion channel signaling in neurovascular barrier regulation and immune cell trafficking.

Current opinion in immunology·2026
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
See all related articles

Non-classical class I genes, found across diverse species, are crucial for immune responses. Their varied distribution and peptide-binding capabilities suggest unexplored functions in immunity.

Area of Science:

  • Immunology
  • Genetics
  • Comparative Biology

Background:

  • Non-classical class I genes present challenges in distinguishing them from classical counterparts in mammals.
  • These genes are evolutionarily conserved, appearing in diverse vertebrate species including fishes, frogs, and chickens.
  • They play a significant role in orchestrating immune responses against various pathogens.

Purpose of the Study:

  • To explore the evolving understanding of non-classical class I genes.
  • To highlight their presence across vertebrate species.
  • To investigate the implications of their diversity and binding capabilities for novel immune functions.

Main Methods:

  • Comparative genomic analysis to identify non-classical class I gene distribution.

Related Experiment Videos

  • Functional assays to assess immune response contributions.
  • Peptide-binding studies to characterize molecular interactions.

    • Main Results:

    • Non-classical class I genes are not exclusively mammalian and are found in fishes, frogs, and chickens.
    • These genes are integral to immune responses against pathogens.
    • Significant diversity exists in class Ib products, with varied tissue distribution and broad peptide-binding specificities.

    Conclusions:

    • The distinction between classical and non-classical class I genes is becoming less defined.
    • The broad presence and functional roles underscore their importance in vertebrate immunity.
    • The diversity and binding properties of class Ib molecules indicate potential for novel immunological functions.