Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antigens recognized by gamma delta T cells

M Kronenberg1

  • 1University of California at Los Angeles School of Medicine.

Current Opinion in Immunology
|February 1, 1994
PubMed
Summary

Gamma delta T cells are crucial for fighting infections, but the specific antigens they recognize are often unknown. Some gamma delta T cells may recognize antigens independently of MHC class I or II molecules.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genes, structures and function of T lymphocyte antigen receptors.

Immunology today·2014
Same author

Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells.

Mucosal immunology·2014
Same author

Escherichia coli infection induces autoimmune cholangitis and anti-mitochondrial antibodies in non-obese diabetic (NOD).B6 (Idd10/Idd18) mice.

Clinical and experimental immunology·2013
Same author

Regulatory T-cell stability and plasticity in mucosal and systemic immune systems.

Mucosal immunology·2010
Same author

Carbohydrate Moieties as Vaccine Candidates: meeting summary.

Vaccine·2008
Same author

TCR-mediated recognition of glycolipid CD1 complexes.

Current topics in microbiology and immunology·2007

Area of Science:

  • Immunology
  • Cellular Biology

Background:

  • Gamma delta T cells play a vital role in host defense against infections.
  • The precise antigens recognized by gamma delta T cells remain largely unidentified.
  • Understanding gamma delta T cell antigen recognition is key to harnessing their therapeutic potential.

Purpose of the Study:

  • To investigate the mechanisms of antigen recognition by gamma delta T cells.
  • To elucidate the role of MHC molecules in gamma delta T cell activation.
  • To identify novel pathways for gamma delta T cell-mediated immunity.

Main Methods:

  • Analysis of gamma delta T cell responses.
  • Investigation of antigen presentation pathways.
  • Utilizing genetic and biochemical approaches to study T cell receptor interactions.

Main Results:

  • Evidence suggests gamma delta T cells can recognize antigens independently of classical MHC class I and II molecules.
  • Certain gamma delta T cell populations appear to utilize non-classical MHC class I molecules for antigen presentation.
  • The diversity of antigen recognition mechanisms employed by gamma delta T cells is highlighted.

Conclusions:

  • Gamma delta T cell antigen recognition is complex and multifaceted.
  • Non-classical MHC class I molecules represent an important pathway for gamma delta T cell activation.
  • Further research into these pathways could lead to new strategies for infection control and immunotherapy.

Related Experiment Videos