Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mast cells: function and contents

L B Schwartz1

  • 1Department of Internal Medicine, Virginia Commonwealth University, Richmond 23298.

Current Opinion in Immunology
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ovarian hyperstimulation syndrome: review and new classification criteria for reporting in clinical trials.

Human reproduction (Oxford, England)·2016
Same author

Proposed diagnostic algorithm for patients with suspected mastocytosis: a proposal of the European Competence Network on Mastocytosis.

Allergy·2014
Same author

Refined diagnostic criteria and classification of mast cell leukemia (MCL) and myelomastocytic leukemia (MML): a consensus proposal.

Annals of oncology : official journal of the European Society for Medical Oncology·2014
Same author

Increased serum baseline tryptase levels and extensive skin involvement are predictors for the severity of mast cell activation episodes in children with mastocytosis.

Allergy·2012
Same author

Serum total tryptase levels are increased in patients with active chronic urticaria.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2010
Same author

Exercise-induced hypersensitivity syndromes in recreational and competitive athletes: a PRACTALL consensus report (what the general practitioner should know about sports and allergy).

Allergy·2008
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026
See all related articles

Activated mast cells release mediators crucial for immediate hypersensitivity. Growth factors regulate mast cell proteases, and human mast cells produce cytokines influencing IgE and inflammation.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Mast cells are key players in immediate hypersensitivity reactions.
  • Mast cell neutral proteases are specific markers whose expression is regulated by growth factors.
  • Human mast cells produce cytokines that impact IgE production and inflammation.

Purpose of the Study:

  • To summarize recent findings on mast cell mediator release.
  • To highlight the role of growth factors in regulating mast cell proteases.
  • To underscore the cytokine production capabilities of human mast cells.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of studies on mast cell activation and mediator release.
  • Examination of research on growth factor regulation of mast cell proteases.

Related Experiment Videos

  • Investigation of cytokine production by human mast cells.

    • Main Results:

    • Activated mast cells release diverse mediators initiating hypersensitivity.
    • Growth factors have been identified as regulators of mast cell neutral protease expression.
    • Human mast cells produce cytokines that modulate IgE levels and inflammatory processes.

    Conclusions:

    • Mast cell activation is central to immediate hypersensitivity.
    • Growth factor signaling pathways influence mast cell protease expression.
    • Human mast cells contribute to immune regulation through cytokine production, impacting IgE and inflammation.