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Intravascular contrast media and thrombin generation
Acta Radiologica (Stockholm, Sweden : 1987)
|March 1, 1994
Summary
Ionic and nonionic contrast media (CM) were tested for effects on thrombin generation. Neither ionic nor nonionic CM enhanced thrombin generation in vitro, suggesting anticoagulant properties.
Area of Science:
- Biochemistry
- Hematology
- Medical Imaging
Background:
- Contrast media (CM) are widely used in medical imaging.
- Understanding the hemostatic effects of CM is crucial for patient safety.
- Previous research has yielded conflicting results regarding CM's impact on coagulation.
Purpose of the Study:
- To investigate the in vitro effect of ionic and nonionic contrast media on thrombin generation.
- To assess the procoagulant activity of nonionic contrast media.
Main Methods:
- Incubation of nonanticoagulated whole blood with ionic CM (diatrizoate, ioxaglate) and nonionic CM (iohexol, iopamidol) or glucose.
- Measurement of thrombin generation markers (F1+2, ATM, FpA) using ELISA.
- Evaluation of procoagulant activity of nonionic CM (iohexol, iopamidol, iopromide) via one-stage plasma recalcification time.
Main Results:
- Incubation with ionic and nonionic CM did not enhance thrombin generation compared to glucose control.
- Plasma recalcification times were not significantly shortened by the tested nonionic CM.
- Ionic and nonionic CM demonstrated no procoagulant activity in vitro.
Conclusions:
- Ionic and nonionic contrast media do not enhance thrombin generation in vitro.
- Nonionic contrast media do not exhibit procoagulant activity.
- These findings suggest that contrast media possess anticoagulant properties in vitro.