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Related Experiment Videos

Mazindol self-administration in the rhesus monkey

M C Wilson, C R Schuster

    Pharmacology, Biochemistry, and Behavior
    |February 1, 1976
    PubMed
    Summary

    Mazindol acts as a reinforcer in monkeys, similar to cocaine. Higher doses per injection led to more self-administration, but total intake remained consistent, indicating reinforcing properties.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Cocaine self-administration models are crucial for understanding addiction.
    • Mazindol's psychomotor stimulant properties suggest potential reinforcing effects.

    Purpose of the Study:

    • To determine if mazindol functions as a reinforcer in a primate model.
    • To investigate the dose-response relationship of mazindol self-administration.

    Main Methods:

    • Monkeys previously trained to self-administer cocaine were used.
    • Intravenous mazindol was administered at various unit dosages (50-200 mug/kg).
    • Self-administration rates and total intake were measured.

    Main Results:

    • Mazindol (50 and 100 mug/kg) significantly increased self-administration compared to saline.
    • An inverse relationship was observed between unit dosage and self-administration frequency.
    • Total daily mazindol intake was independent of unit dosage, suggesting reinforcing effects across tested doses.

    Conclusions:

    • Mazindol acts as a positive reinforcer in non-human primates.
    • The self-administration patterns of mazindol resemble those of other psychomotor stimulants.
    • This supports further investigation into mazindol's neurobiological mechanisms related to reward.

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