[Relationship between insulin resistance and blood pressure]

Area of Science:

• Metabolic Syndrome Research
• Cardiovascular Health Studies
• Endocrinology

Background:

• Insulin resistance is a key factor in metabolic dysfunction.
• Understanding the link between insulin resistance and hypertension is crucial for public health.
• Previous research suggests a connection, but further clarification is needed.

Purpose of the Study:

• To investigate the relationship between blood pressure and markers of insulin resistance.
• To identify anthropometric and metabolic factors associated with hypertension in a non-diabetic population.

Main Methods:

• Cross-sectional study of 353 participants without overt diabetes.
• Measurement of fasting plasma insulin (IRI), fasting plasma glucose (FPG), BMI, WHR, body fat percentage, lipids, and urine sodium.
• Correlation and multiple regression analyses were performed.

Main Results:

• Hypertensive subjects showed significantly higher age, IRI, FPG, WHR, total cholesterol, and BMI.
• IRI, WHR, and BMI were found to be intercorrelated.
• Adjusted analyses confirmed IRI, WHR, and BMI as significant predictors of mean blood pressure.

Conclusions:

• Fasting plasma insulin (IRI) serves as a reliable indicator of insulin resistance.
• Insulin resistance, indicated by IRI, along with WHR and BMI, is significantly associated with elevated blood pressure.