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Critical period control in sensory cortex

K Fox1, K Zahs

  • 1Department of Physiology, University of Minnesota, Minneapolis 55455.

Current Opinion in Neurobiology
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

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Researchers are identifying factors that end critical periods for brain plasticity. NMDA receptors and neurotrophins play key roles, with neurotrophins blocking plasticity in the visual cortex.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • The critical period for experience-dependent cortical plasticity ends due to regulatory factors during development.
  • N-methyl-D-aspartate (NMDA) receptors and neurotrophins are implicated in this developmental process.
  • Developmental regulation of NMDA receptor subunits alters receptor kinetics.

Purpose of the Study:

  • To investigate the roles of NMDA receptors and neurotrophins in the closure of the critical period for cortical plasticity.
  • To understand how developmental factors and neuronal activity regulate neurotrophin and receptor expression.
  • To examine the effect of exogenous neurotrophins on visual cortex plasticity.

Main Methods:

  • Analysis of NMDA receptor subunit regulation during development.

Related Experiment Videos

  • Monitoring of mRNA expression for neurotrophins and their receptors.
  • Experimental manipulation using exogenous neurotrophins in the visual cortex.

    • Main Results:

    • NMDA receptor subunits exhibit developmental regulation impacting receptor function.
    • Neurotrophin and receptor mRNA expression are modulated by developmental cues and neuronal activity.
    • Application of exogenous neurotrophins inhibits critical period plasticity in the visual cortex.

    Conclusions:

    • NMDA receptors and neurotrophins are crucial regulators of critical period plasticity.
    • Developmental changes in these systems contribute to the cessation of experience-dependent cortical plasticity.
    • Neurotrophins, in particular, can actively block plasticity, highlighting their role in developmental timing.