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The pseudotumor cerebri

R Boeri1

  • 1Istituto Nazionale Neurologico C. Besta, Milano, Italy.

Current Opinion in Neurology
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

Pseudotumor cerebri, characterized by papilledema and normal ventricles, is diagnosed by exclusion. Its pathogenesis involves sluggish intracranial venous circulation and cerebral edema, leading to a consistent syndrome with varied presentations.

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Area of Science:

  • Neurology
  • Neuroscience
  • Ophthalmology

Background:

  • Pseudotumor cerebri is a clinical syndrome characterized by papilledema and normal cerebral ventricles.
  • Diagnosis is often made by excluding other conditions like space-occupying lesions or infections.
  • The syndrome presents with varied clinical signs and pathogenesis depending on etiology.

Purpose of the Study:

  • To elucidate the underlying mechanisms and pathogenesis of pseudotumor cerebri.
  • To consolidate understanding of the diagnostic criteria and clinical presentation.
  • To review current knowledge on the etiologies contributing to the syndrome.

Main Methods:

  • Review of epidemiological, clinical, and neuroradiological research.
  • Analysis of experimental data on intracranial circulation and cerebral edema.

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  • Diagnostic exclusion based on clinical and radiological findings.

    • Main Results:

    • Pseudotumor cerebri pathogenesis involves sluggish intracranial venous circulation, increased cerebral blood volume, and impaired cerebrospinal fluid absorption.
    • Cerebral edema, either hypo-osmolar or vasogenic, is a key component.
    • The syndrome's clinical expression varies based on the interplay of these pathophysiological factors.

    Conclusions:

    • Pseudotumor cerebri is a complex syndrome with multifactorial etiology.
    • Understanding the roles of venous circulation and cerebral edema is crucial for diagnosis and management.
    • Further research into specific etiologies can refine understanding and treatment approaches.