In vivo protein synthesis in morphine tolerant monkey brain

Most investigations dealing with brain protein synthesis in opiate tolerant animals have been restricted to rodent species (rat, mouse and rabbit). We now report data obtained from the monkey (Macaca mulatta). In vivo incorporation of [U-14C]lysine into acid-precipitable protein of various areas of normal and opiate tolerant primate brain was studied. Exposure of the animals to a 1 hour pulse of the radioactive amino acid resulted in no significant difference in the incorporation rate into protein of 16 discrete brain areas.