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A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
Published on: July 28, 2018
Temporal variability and correlation with geometric parameters in vasospastic angina: a quantitative angiographic
1Department of Interventional Cardiology, Erasmus University, Rotterdam, The Netherlands.
European Heart Journal
|January 1, 1994
Summary
Coronary artery vasospasticity changes over time in variant angina patients. Geometric theory does not accurately predict these dynamic changes in vasocontractility.
Area of Science:
- Cardiology
- Vascular Physiology
Background:
- Variant angina is characterized by dynamic coronary artery vasospasm.
- Understanding long-term changes in vasocontractility is crucial for managing variant angina.
Purpose of the Study:
- To investigate long-term changes in coronary vasocontractility in patients with variant angina.
- To assess the predictive accuracy of a geometric theory for vasospasticity.
Main Methods:
- Quantitative coronary angiography and ergonovine provocation tests were performed on 23 coronary segments from 20 patients.
- Tests were repeated after 42 +/- 14 months to evaluate temporal changes.
- Vasospasticity measurements were compared against predictions from a geometric theory assuming constant vessel wall cross-sectional area.
Main Results:
- Initially, 18 of 23 segments showed hypercontractility, one hypocontractility, and four predicted responses.
- At follow-up, vasospastic responsiveness demonstrated significant temporal variability.
- The geometric theory accurately predicted vasospasticity in only one segment across both tests, highlighting its limitations.
Conclusions:
- Coronary vasospastic responsiveness is a dynamic process with significant temporal variability.
- Current geometric theories do not reliably predict long-term changes in vasospasticity at fixed stenotic sites.
- Further research is needed to develop models that capture the dynamic nature of vasospasm.
