Corticosterone suppresses the expression of 5-HT1A receptor mRNA in rat dentate gyrus
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1Leiden/Amsterdam Center for Drug Research, Sylvius Laboratories, The Netherlands.
European Journal of Pharmacology
|February 15, 1994
Abstract:
The effect of corticosterone on 5-HT1A receptor mRNA expression in different hippocampal cell fields was studied by in situ hybridisation. One week after adrenalectomy or chronic corticosterone treatment, the 5-HT1A receptor mRNA showed a negative, but not linear, correlation with plasma corticosterone levels over a wide concentration range, specifically in the dentate gyrus. The data suggest an involvement of the mineralocorticoid receptor in the regulation of the 5-HT1A receptor mRNA and a possible synergistic effect of additional glucocorticoid receptor activation.