Mouse Ly-gene haplotypes and subcutaneous regression of Ehrlich ascites tumor

Ehrlich ascites tumor cells (EAT cells) lack most cell surface H-2 antigens and grow in any mouse strain following intraperitoneal injection of 10(5) cells. With subcutaneous injection of 2 x 10(7) cells, however, EAT regressed in C57BL/10 (H-2b), BALB/c (H-2d), NZB (H-2d), A (H-2a) and SJL (H-2s) but progressed and formed a solid tumor in DBA/2 (H-2d), C3H (H-2k), AKR (H-2k), CBA (H-2k) and DBA/1 (H-2q). By genotype analysis, Ly haplotypes of EAT-regressive mouse strains were found to have Ly-1.2 and Ly-2.2 as common features, while EAT-progressive mouse strains had Ly-1.1 (except AKR) and Ly-2.1.