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Thioridazine enantiomers in human tissues
S A Jortani1, J C Valentour, A Poklis
1Department of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0597.
Forensic Science International
|February 1, 1994
Abstract:
Enantiomers of thioridazine (TRZ) were determined in postmortem tissues obtained from a patient on chronic TRZ therapy by sequential achiral and chiral high pressure liquid chromatography. Tissue concentrations of (+)-TRZ found in liver, brain, bile and blood were: 6.46, 0.40, 0.48 and 0.07 mg/l or mg/kg, respectively. Concentrations of (-)-TRZ in liver, brain, bile and blood were: 12.2, 0.81, 1.07 and 0.20 mg/l or mg/kg, respectively. These data demonstrate the stereoselective disposition of TRZ in human tissues.