Related Experiment Videos
Thioridazine enantiomers in human tissues
S A Jortani1, J C Valentour, A Poklis
1Department of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0597.
Forensic Science International
|February 1, 1994
Summary
This study measured thioridazine (TRZ) enantiomers in postmortem tissues. The findings reveal stereoselective distribution of TRZ in human organs, with the (-) enantiomer being more concentrated.
Area of Science:
- Pharmacology
- Analytical Chemistry
- Forensic Toxicology
Background:
- Thioridazine (TRZ) is an antipsychotic medication with known stereoselective metabolism.
- Understanding the tissue distribution of TRZ enantiomers is crucial for interpreting postmortem findings and clinical effects.
Observation:
- Achiral and chiral high-performance liquid chromatography were used to quantify TRZ enantiomers in postmortem tissues.
- Tissue samples analyzed included liver, brain, bile, and blood from a patient undergoing chronic TRZ therapy.
Findings:
- Concentrations of (+)-thioridazine were 6.46 mg/kg (liver), 0.40 mg/kg (brain), 0.48 mg/kg (bile), and 0.07 mg/kg (blood).
- Concentrations of (-)-thioridazine were 12.2 mg/kg (liver), 0.81 mg/kg (brain), 1.07 mg/kg (bile), and 0.20 mg/kg (blood).
- The (-)-enantiomer of TRZ was consistently found at higher concentrations than the (+)-enantiomer across all analyzed tissues.
Implications:
- These results demonstrate a stereoselective disposition of thioridazine in human tissues.
- The differential distribution of TRZ enantiomers may influence the drug's pharmacological effects and toxicity.
- This stereoselective distribution is important for forensic analysis and understanding drug behavior in vivo.