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Related Experiment Videos

Chloroquine induced mania

S Akhtar1, S Mukherjee

  • 1Central Institute of Psychiatry, Ranchi, India.

International Journal of Psychiatry in Medicine
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Chloroquine can induce mania in susceptible individuals, leading to secondary manic syndrome. Careful monitoring is advised, especially for those with a predisposition to bipolar disorders.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Antimalarial drugs like chloroquine are widely used.
  • Potential adverse effects of chloroquine on mental health require investigation.

Purpose of the Study:

  • To determine if chloroquine monotherapy can precipitate manic episodes.
  • To characterize the clinical course of chloroquine-induced mania.

Main Methods:

  • Case identification of manic episodes occurring post-chloroquine use.
  • Inclusion of community-observed cases.
  • Longitudinal follow-up of affected individuals.

Main Results:

  • Six cases of chloroquine-induced mania were identified.

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  • Two distinct subtypes with variable severity and recurrence patterns were observed.
  • Individual susceptibility to recurrence upon re-exposure varied.

    • Conclusions:

    • Chloroquine is capable of inducing secondary mania.
    • Caution is recommended when prescribing chloroquine to individuals with a predisposition to manic episodes.