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BE-23372M, a novel protein tyrosine kinase inhibitor. III. Synthesis
S Tanaka1, T Okabe, S Nakajima
1Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Japan.
The Journal of Antibiotics
|March 1, 1994
Abstract:
In a preceding paper, the physico-chemical properties and structural elucidation of BE-23372M, a potent novel protein tyrosine kinase inhibitor, were described. In this paper, we report the synthesis of BE-23372M from 3-(3,4-dimethoxybenzoyl)propionic acid and veratraldehyde or 3,4-diacetoxy-benzaldehyde. The structure of BE-23372M was confirmed to be (E)-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)-2(3H)-fur anone.