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Quantifying local lung perfusion and ventilation using correlated SPECT and CT data

E M Damen¹, S H Muller, L J Boersma

¹Department of Radiotherapy, Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis), Amsterdam.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine

|May 1, 1994

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A new method accurately quantifies regional lung perfusion and ventilation using SPECT scans, improving lung function assessment and treatment monitoring in patients with pulmonary disease.

Area of Science:

Nuclear Medicine
Radiology
Pulmonary Medicine

Background:

Assessing regional lung function is crucial for managing pulmonary diseases.
Current methods for quantifying lung perfusion and ventilation using SPECT have limitations.

Purpose of the Study:

To develop and evaluate a clinically applicable method for quantifying subregional lung perfusion and ventilation using SPECT.
To enable accurate estimation of local lung function and monitoring of treatment effects in patients with pulmonary disease.

Main Methods:

Developed a novel algorithm for quantifying local ventilation from SPECT data without assuming homogeneity.
Applied a post-reconstruction correction method for photon attenuation and scatter using CT data.
Evaluated the method on clinical data from patients with normal lung function and radiation-induced pulmonary dysfunction.

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Main Results:

Attenuation correction significantly altered local perfusion and ventilation values (10%-15% difference).
The new ventilation quantification yielded 10%-50% lower values compared to homogeneous ventilation algorithms.
Correction factors ranged from 2.0-3.0 for 81mKr and 2.3-3.5 for 99mTc.

Conclusions:

The developed SPECT-based method provides robust and realistic quantification of lung perfusion and ventilation distribution.
The method achieves an intrinsic accuracy of approximately 10%, suitable for clinical application.
This technique enhances the ability to assess local lung function and treatment response.