Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A fiber-optically coupled positron-sensitive surgical probe

R R Raylman1, R L Wahl

  • 1Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-05520.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|May 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Construction and evaluation of a large radiation detector for Positron Emission Tomography applications.

Journal of instrumentation : an IOP and SISSA journal·2025
Same author

Perspectives on joint EANM/SNMMI/ANZSNM practice guidelines/procedure standards for [<sup>18</sup>F]FDG PET/CT imaging during immunomodulatory treatments in patients with solid tumors.

Cancer imaging : the official publication of the International Cancer Imaging Society·2022
Same author

Joint EANM/SNMMI/ANZSNM practice guidelines/procedure standards on recommended use of [<sup>18</sup>F]FDG PET/CT imaging during immunomodulatory treatments in patients with solid tumors version 1.0.

European journal of nuclear medicine and molecular imaging·2022
Same author

Evaluation of Hamamatsu PET imaging modules for dedicated TOF-capable scanners.

IEEE transactions on radiation and plasma medical sciences·2021
Same author

Factors affecting the repeatability of gamma camera calibration for quantitative imaging applications using a sealed source.

Physics in medicine and biology·2015
Same author

Understanding the Role of 18Flurodeoxyglucose PET in Predicting Improved Survival in Locally Advanced Pancreatic Cancer.

Practical radiation oncology·2014

A new plastic scintillator probe effectively detects positron-emitting isotopes like 18F-labeled 2-deoxy-D-glucose (FDG) during surgery, even with high background radiation. This technology aids in precise tumor localization for improved intraoperative guidance.

Area of Science:

  • Nuclear Medicine
  • Medical Instrumentation
  • Surgical Technology

Background:

  • Positron-emitting radiopharmaceuticals, such as 18F-labeled 2-deoxy-D-glucose (FDG), are crucial for noninvasive cancer imaging due to their tumor-localizing properties.
  • Current positron-sensitive probes struggle with high background photon flux from positron annihilation, limiting their surgical guidance utility.
  • Precise delineation of FDG-avid tumors is possible due to the short range of positrons, suggesting potential for surgical guidance.

Purpose of the Study:

  • To design, manufacture, and test a novel positron-sensitive probe system.
  • To evaluate the probe's performance in detecting positron-emitting isotopes in high-photon background environments.
  • To assess the probe's suitability for intraoperative guidance in surgeries involving FDG or similar tracers.

Related Experiment Videos

Main Methods:

  • A plastic scintillator probe coupled via fiber-optic cable to a photomultiplier tube was developed.
  • Detector resolution and sensitivity were measured.
  • The impact of varying levels of background photon flux on probe resolution was quantified.

Main Results:

  • The probe demonstrated minimal resolution degradation (approx. 5%) in a 2:1 background-to-source ratio.
  • High sensitivity for positrons was achieved, detecting as little as 10.2 nCi of FDG in vitro.
  • In vivo studies in rats successfully detected lymph nodes with as little as 11 nCi of FDG.

Conclusions:

  • A plastic scintillator probe system has been successfully developed.
  • The probe is well-suited for detecting positron-emitting isotopes in challenging high-photon backgrounds.
  • This system shows significant potential for intraoperative guidance in surgeries utilizing FDG or other positron/beta-emitting tracers.