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Related Experiment Videos

Sertoli cell function declines earlier than Leydig cell function in aging Japanese men

M Haji1, S Tanaka, Y Nishi

  • 1Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Maturitas
|February 1, 1994
PubMed
Summary

Male reproductive hormones like total testosterone (TT) and free testosterone (FT) decline with age in Japanese men, with Sertoli cell function decreasing before Leydig cell function.

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Area of Science:

  • Endocrinology
  • Reproductive Biology
  • Gerontology

Background:

  • Aging is associated with hormonal changes in men.
  • Leydig cells produce testosterone, while Sertoli cells are involved in spermatogenesis and inhibin production.
  • Understanding age-related endocrine function is crucial for male health.

Purpose of the Study:

  • To investigate age-related changes in Leydig and Sertoli cell function in healthy Japanese men.
  • To analyze serum levels of key reproductive hormones and gonadotropins across different age groups.

Main Methods:

  • Serum levels of total testosterone (TT), free testosterone (FT), inhibin, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured.
  • 116 healthy Japanese men aged 24-92 years were studied.

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  • Men were categorized into young (24-39), middle-aged (40-59), and aged (60-92) groups.

    • Main Results:

    • Serum TT remained stable until age 80, then decreased. Serum FT declined linearly with age.
    • Serum inhibin levels decreased significantly after age 40 and markedly after age 80.
    • LH and FSH levels increased in men over 60 and 40, respectively. Inverse correlation between FSH and inhibin was observed in middle-aged and aged men.

    Conclusions:

    • Testicular endocrine function declines after the fourth decade in Japanese men.
    • Sertoli cell function appears to decline earlier than Leydig cell function.
    • Age-related hormonal changes show distinct patterns in gonadotropins and gonadal hormones.