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Alterations in epithelial polarity and the pathogenesis of disease states
1Department of Medicine, University of Colorado School of Medicine, Denver.
The New England Journal of Medicine
|June 2, 1994
Abstract:
The establishment and maintenance of epithelial-cell polarity are prerequisites for normal epithelial-cell and organ function. Knowledge of the processes involved in cell polarity has provided insight into the mechanisms of cell dysfunction and the pathogenesis of several diseases. These insights should lead to the development of specific strategies aimed at preventing or minimizing the progression of these diseases.