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The effect of repeated administration of methamphetamine on dopamine uptake sites in rat striatum
K Ikawa1, A Watanabe, N Motohashi
1Department of Neuropsychiatry, Tokyo Metropolitan Hiroo General Hospital, Japan.
Abstract:
In this experiment, rats were injected intraperitoneally with 6 mg/kg methamphetamine (MAP) hydrochloride or the same volume of saline once daily for 14 days. Rats were decapitated after a 1-day, 4-day or 10-day withdrawal period. The number and affinity of [3H]mazindol binding sites in the striatum were measured. Their number in the MAP group decreased as compared with controls after a 1-day withdrawal period, but returned to the control level after a 4-day and 10-day withdrawal period. These results are believed to show that the decrease in dopamine uptake sites after repeated administration of MAP is transient and does not contribute to MAP-induced behavioral sensitization.