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Related Experiment Videos

Folate responsive neuropathy

T E Parry

    Presse Medicale (Paris, France : 1983)
    |January 29, 1994
    PubMed
    Summary
    This summary is machine-generated.

    Folate deficiency can cause serious neurological issues like neuropathy and spinal cord degeneration. Early diagnosis and folic acid treatment are crucial for recovery and preventing irreversible damage.

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    Area of Science:

    • Neurology
    • Nutritional Neuroscience
    • Hematology

    Background:

    • Folate deficiency is linked to neurological disorders.
    • Vitamin B12 deficiency also causes similar neurological symptoms.
    • Distinguishing between the two is critical for effective treatment.

    Purpose of the Study:

    • To review the literature on folate-related neuropathy.
    • To identify diagnostic criteria for folate deficiency neurological disorders.
    • To investigate the biochemical basis of these neurological conditions.

    Main Methods:

    • Literature review of folate-related neuropathy.
    • Analysis of 20 patients with neurological findings, low folate levels, and normal vitamin B12.
    • Assessment of patient response to folic acid treatment.

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    Main Results:

    • Ten patients had peripheral neuropathy, eight had subacute combined degeneration, and two had myelopathy.
    • Neuropathy recurred in two patients when folate treatment lapsed.
    • Mental changes and retardation also responded to folic acid therapy.

    Conclusions:

    • Low folate levels, even with normal vitamin B12, can cause significant neurological damage.
    • The methionine synthetase reaction is implicated in both folate and vitamin B12 deficiency neurological consequences.
    • Increased awareness and prompt diagnosis of folate deficiency are urged to prevent severe neurological outcomes.