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Updated: Aug 10, 2026

Preparing T Cell Growth Factor from Rat Splenocytes
18:27

Preparing T Cell Growth Factor from Rat Splenocytes

Published on: October 31, 2007

Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor

K H Grabstein1, J Eisenman, K Shanebeck

  • 1Immunex Research and Development Corporation, Seattle, WA 98101.

Science (New York, N.Y.)
|May 13, 1994
PubMed

A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor.

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