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[Urogenital malformation complex including the Mullerian system]
W Hochreiter1, A Stenzl, H J Altermatt
1Urologische Universitätsklinik, Inselspital, Bern.
Der Urologe. Ausg. A
|March 1, 1994
Abstract:
Symptomatic cystic epididymis in a 21-year-old man led to the detection of several genital malformations, including a partially obstructing pelvic cyst, prostatic and bilateral testicular atrophy and penoscrotal hypospadias. These malformations are probably due to a deficiency of either testosterone or müllerian inhibiting hormone (MIH). Development of the male genitalia is influenced by testosterone secreted in the Leydig cells during weeks 8-16 of gestation, while regression of the müllerian ducts is induced by MIH secreted in the Sertoli cells from weeks 9-12 of gestation.