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Granular cell tumors

M Kershisnik1, J G Batsakis, B Mackay

  • 1Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston 77030.

The Annals of Otology, Rhinology, and Laryngology
|May 1, 1994
PubMed
Summary
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Granular cell tumors commonly affect the head and neck, presenting in infantile or noncongenital forms. Marginal excision leads to a 15% recurrence rate for these enigmatic lesions.

Area of Science:

  • Oncology
  • Dermatopathology
  • Head and Neck Surgery

Background:

  • Granular cell tumors (GCTs) are rare neoplasms with a predilection for the skin, subcutaneous tissue, and mucosae of the head and neck.
  • These tumors present distinct clinicopathologic forms: infantile (congenital) epulis and noncongenital soft tissue/aerodigestive GCTs.
  • The histogenesis of granular cell tumors remains largely enigmatic.

Purpose of the Study:

  • To review the clinicopathologic presentations of granular cell tumors in the head and neck.
  • To discuss the recurrence rates associated with different forms of GCTs.
  • To highlight the diagnostic criteria for malignant granular cell tumors.

Main Methods:

  • Review of clinicopathologic features of granular cell tumors.

Related Experiment Videos

  • Analysis of recurrence patterns based on surgical technique.
  • Discussion of histological criteria for malignancy.

    • Main Results:

    • Head and neck sites are common locations for granular cell tumors.
    • Recurrence rates approach 15% for both infantile and noncongenital forms, often linked to marginal excision.
    • Malignant granular cell tumors are recognized but require stringent histological confirmation.

    Conclusions:

    • Granular cell tumors exhibit distinct presentations in the head and neck region.
    • Incomplete surgical excision is a primary driver of recurrence.
    • Accurate histological evaluation is critical for diagnosing malignant variants.