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Related Experiment Videos

Superior sulcus tumors: combined modality

D B Fuller1, J S Chambers

  • 1Radiation Medical Group, Inc., San Diego, California.

The Annals of Thoracic Surgery
|May 1, 1994
PubMed
Summary
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High-dose preoperative radiotherapy combined with surgery improved long-term survival for superior sulcus tumors. This aggressive approach showed promising results with acceptable morbidity in advanced lung cancer patients.

Area of Science:

  • Thoracic Oncology
  • Surgical Oncology
  • Radiation Oncology

Background:

  • Superior sulcus tumors are challenging to treat.
  • Combined-modality therapy is often necessary for locally advanced disease.

Purpose of the Study:

  • To evaluate the efficacy and safety of combined-modality therapy for superior sulcus tumors.
  • To assess the impact of high-dose preoperative radiotherapy on survival outcomes.

Main Methods:

  • Retrospective review of 24 patients with superior sulcus tumors treated between 1955 and 1989.
  • Fifteen patients received combined-modality therapy, including preoperative radiotherapy (5,500–6,475 cGy) followed by en bloc resection in 13 patients.

Main Results:

  • Seven of 13 patients receiving preoperative radiotherapy survived disease-free beyond 5 years.

Related Experiment Videos

  • Two additional patients had no evidence of disease after >2 years.
  • Morbidity was within accepted limits, with one postoperative death in an octogenarian.

    • Conclusions:

    • High-dose preoperative radiotherapy followed by surgery is feasible and associated with superior long-term survival for superior sulcus tumors.
    • This approach may be beneficial for other locally advanced (stage III) bronchogenic carcinomas.