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Radiopacity study of extended-release formulations using digitalized radiography
D J Tillman1, D L Ruggles, J B Leikin
1Department of Pharmacy Practice, University of Illinois, Chicago Hospital and Clinics 60612-7230.
The American Journal of Emergency Medicine
|May 1, 1994
Summary
Digital radiography significantly improves the detection of ingested medications in vitro. Further in-vivo studies are recommended to establish the sensitivity of digital radiography for acute toxic ingestions.
Area of Science:
- Radiology
- Toxicology
- Pharmaceutical Sciences
Background:
- Radiography is crucial for assessing toxic ingestions.
- Evaluating radiopacity of oral dosage forms is important for detection.
Purpose of the Study:
- To assess radiography's role in managing toxic ingestions.
- To compare radiopacity of extended-release vs. basic oral formulations using standard and digital radiography in vitro.
Main Methods:
- Oral medications were tested in an in vitro human abdomen model.
- Standard and digitized radiography were used, with images digitally enhanced.
- Radiopacity was compared to ferrous sulfate.
Main Results:
- Digital enhancement of standard radiographs increased detection by 100%.
- No significant difference in radiopacity between extended-release and basic formulations was found.
- Capsules were more radiolucent than the surrounding in vitro model.
Conclusions:
- Digital enhancement of radiographs improves oral dosage form detectability in vitro.
- Further in-vivo research using digital radiography for acute toxic ingestions is warranted.