Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structure, function and expression of voltage-dependent sodium channels

R G Kallen1, S A Cohen, R L Barchi

  • 1Mahoney Institute of Neurological Sciences, University of Pennsylvania School of Medicine, Philadelphia.

Molecular Neurobiology
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A diagnostic to measure neutral-atom density in fusion-research plasmas.

The Review of scientific instruments·2022
Same author

Evaluation of a collisional radiative model for electron temperature determination in hydrogen plasma.

The Review of scientific instruments·2022
Same author

Use of a Mylar filter to eliminate vacuum ultraviolet pulse pileup in low-energy x-ray measurements.

The Review of scientific instruments·2022
Same author

Simulating single-particle dynamics in magnetized plasmas: The RMF code.

The Review of scientific instruments·2022
Same author

The Association between Physical Activity and Metabolic Syndrome in Older Adults with Obesity.

The Journal of frailty & aging·2019
Same author

Relationship between Diet Quality, Physical Activity and Health-Related Quality of Life in Older Adults: Findings from 2007-2014 National Health and Nutrition Examination Survey.

The journal of nutrition, health & aging·2018

Voltage-dependent sodium channels are crucial for action potentials in excitable cells. Recent research advances understanding of their structure, function, gene expression, and links to human diseases.

Area of Science:

  • Molecular biology
  • Neuroscience
  • Biophysics

Background:

  • Voltage-dependent sodium channels (Nav channels) generate action potentials in excitable cells.
  • The Nav channel multigene family has been extensively studied through cloning, sequencing, and functional expression.
  • Understanding Nav channel structure-function relationships is key to cellular electrophysiology.

Purpose of the Study:

  • To review recent advances in voltage-dependent sodium channel research.
  • To highlight the importance of Nav channel structure, function, and regulation.
  • To discuss the role of Nav channel mutations in human diseases.

Main Methods:

  • Cloning, sequencing, and functional expression of Nav channel genes.
  • Site-directed mutagenesis and in vitro expression studies.

Related Experiment Videos

  • Analysis of Nav channel gene expression regulation and functional modulation.

    • Main Results:

    • Common structural features of Nav channels have been identified.
    • Structure-function relationships have been elucidated through mutagenesis.
    • Nav channel isoforms exhibit subtle functional differences.
    • Nav channel mutations are linked to human disease pathophysiology.

    Conclusions:

    • Recent advances have significantly improved our understanding of voltage-dependent sodium channels.
    • Further research into Nav channel regulation and disease links is crucial.
    • Nav channels are critical targets for understanding both normal physiology and disease states.