Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Islet microencapsulation: a review

H A Clayton1, R F James, N J London

  • 1Department of Surgery, University of Leicester, UK.

Acta Diabetologica
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient reported outcomes and implant survivorship after Total knee arthroplasty with the persona knee implant system: two year follow up.

BMC musculoskeletal disorders·2019
Same author

No demonstrable benefit for coronal alignment outcomes in PSI knee arthroplasty: A systematic review and meta-analysis.

Orthopaedics & traumatology, surgery & research : OTSR·2015
Same author

Gender differences in distal femoral morphology and the role of gender specific implants in total knee replacement: a prospective clinical study.

The Knee·2011
Same author

Telomere length dynamics in vascular disease: a review.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2010
Same author

Functional recovery of stepping in rats after a complete neonatal spinal cord transection is not due to regrowth across the lesion site.

Neuroscience·2009
Same author

Conservative management of type 2 endoleaks is not associated with increased risk of aneurysm rupture.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2009
Same journal

Combined respiratory muscle training and photobiomodulation improve systemic and tissue-specific redox homeostasis in a rat model of type 2 diabetes.

Acta diabetologica·2026
Same journal

Quality of care for migrant populations with type 2 diabetes mellitus in Italy: a retrospective analysis of data from the the Italian AMD (Associations of Medical Diabetologists) annals initiative.

Acta diabetologica·2026
Same journal

Bidirectional association between obstructive sleep apnea and diabetic retinopathy: a severity-stratified systematic review and meta-analysis with GRADE assessment.

Acta diabetologica·2026
Same journal

Therapeutic strategies to enhance proliferation in diabetic wound contraction: a comprehensive review from 1991-2025.

Acta diabetologica·2026
Same journal

Adjunctive use of glucagon-like peptide-1 receptor agonists after bariatric surgery: updated systematic review and meta-analysis of randomized controlled trials.

Acta diabetologica·2026
Same journal

Clarifying metformin exposure when interpreting glycemic responses after imeglimin initiation.

Acta diabetologica·2026
See all related articles

Encapsulating islets of Langerhans in alginate-poly-L-lysine-alginate shows promise for type 1 diabetes treatment. Overcoming capsule fibrosis in transplantation remains a key challenge for long-term graft function.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Diabetes Research

Background:

  • Islet microencapsulation using alginate and poly-L-lysine (PLL) was initially reported.
  • Alginate-PLL-alginate encapsulation has been extensively studied for islet transplantation.
  • In vitro studies show high viability of encapsulated islets, but in vivo results vary.

Purpose of the Study:

  • To review studies on alginate-PLL-alginate encapsulated islets.
  • To analyze challenges and advancements in islet encapsulation for type 1 diabetes.
  • To assess the potential of encapsulated islet transplants as a viable treatment.

Main Methods:

  • Review of existing literature on alginate-PLL-alginate islet microencapsulation.
  • Analysis of transplantation outcomes in chemically induced and naturally occurring diabetic models.

Related Experiment Videos

  • Examination of factors contributing to graft failure, particularly pericapsular fibrosis.

    • Main Results:

    • Excellent in vitro islet viability is consistently demonstrated.
    • Transplantation outcomes are variable, with graft failure often linked to pericapsular fibrosis.
    • Naturally occurring diabetic models exhibit more severe fibrosis and graft dysfunction compared to chemically induced models.

    Conclusions:

    • Pericapsular fibrosis is the primary obstacle to successful encapsulated islet transplantation.
    • Recent improvements in alginate purification and islet size reduction are significant advancements.
    • Encapsulated islet transplantation holds potential for treating type 1 diabetes, pending further research to overcome fibrosis.