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Early lymphoid blastic crisis following major karyotypic conversion in a chronic myeloid leukemia patient treated
A Ambrosetti1, M Krampera, D Veneri
1Cattedra di Ematologia, Policlinico Borgo Roma, Verona, Italy.
International Journal of Clinical & Laboratory Research
|January 1, 1994
Abstract:
A major karyotypic conversion following interferon-alpha treatment delays or prevents blastic crisis in patients with chronic myeloid leukemia. We report here a 12-year-old boy with Ph1+ chronic myeloid leukemia who, after achieving a major karyotypic conversion following 12 months interferon-alpha treatment, developed an early lymphoid blastic transformation 7 months later while still under interferon-alpha therapy. A number of possible explanations for this quite unexpected event are discussed.