Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

56
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
56
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

2.1K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
2.1K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

10.8K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.8K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

11.7K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
11.7K
Cancer Prevention02:59

Cancer Prevention

8.5K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Performance of ChatGPT in French language analysis of multimodal retinal cases.

Journal francais d'ophtalmologie·2024
Same author

Effect of high-flow nasal oxygen on hypoxaemia during procedural sedation: a systematic review and meta-analysis.

Anaesthesia·2022
Same author

Evidence-based Canadian guidelines for tele-retina screening for diabetic retinopathy: recommendations from the Canadian Retina Research Network (CR2N) Tele-Retina Steering Committee.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2020
Same author

Inhibition of respiration by aureomycin and terramycin.

Antibiotics & chemotherapy (Northfield, Ill.)·2014
Same author

Utility of mesenchymal stromal cells for myocardial infarction. Transitioning from bench to bedside.

Minerva cardioangiologica·2013
Same author

Cardiac magnetic resonance, transthoracic and transoesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats.

Laboratory animals·2013

Related Experiment Video

Updated: Mar 6, 2026

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

1.3K

TGF-alpha and oral carcinogenesis

D T Wong1

  • 1Laboratory Molecular Carcinogenesis, Department of Oral Medicine, Harvard School of Dental Medicine, Boston, Massachusetts 02115.

European Journal of Cancer. Part B, Oral Oncology
|January 1, 1993
PubMed
Summary

Transforming growth factor-alpha (TGF-alpha) and its receptor, epidermal growth factor receptor (EGFR), are key in oral cancer. Eosinophils are a newly identified source of TGF-alpha in oral tumors.

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Biology

Background:

  • Transforming growth factor-alpha (TGF-alpha) and epidermal growth factor receptor (EGFR) are implicated in epithelial tumor growth.
  • Elevated TGF-alpha and EGFR expression is observed in various carcinomas, including oral squamous cell carcinomas.
  • The autocrine TGF-alpha/EGFR pathway is a proposed mechanism for uncontrolled tumor proliferation.

Purpose of the Study:

  • To investigate the cellular sources and expression levels of TGF-alpha and EGFR in oral cancer.
  • To elucidate the role of TGF-alpha and EGFR in the development of oral cancer using an animal model.

Main Methods:

  • RNA blotting analyses to quantify TGF-alpha and EGFR expression levels.
  • In situ hybridization and immunohistochemistry to determine cellular localization of TGF-alpha.

More Related Videos

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

15.6K
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

12.4K

Related Experiment Videos

Last Updated: Mar 6, 2026

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

1.3K
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

15.6K
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

12.4K
  • Utilizing a hamster oral cancer model for in vivo studies.

    • Main Results:

    • Consistent elevated expression of TGF-alpha and EGFR in human and hamster oral cancers.
    • Identification of eosinophils as a significant cellular source of TGF-alpha within oral tumor microenvironments.
    • Association of eosinophil presence with malignant oral epithelium and elevated EGFR expression in transformed epithelium.

    Conclusions:

    • Quantitative changes in TGF-alpha and EGFR are observed in the oral tumor microenvironment.
    • Eosinophils represent a novel cellular source of TGF-alpha contributing to oral cancer development.
    • The hamster oral cancer model provides a platform to study the molecular mechanisms of TGF-alpha and EGFR in oral carcinogenesis.