Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene transfer and vascular disease

E G Nabel1, V J Pompili, G E Plautz

  • 1University of Michigan Medical Center, Ann Arbor 48109-0688.

Cardiovascular Research
|April 1, 1994
PubMed
Summary

Gene transfer advances molecular biology, enabling study of gene regulation in cardiovascular diseases. This technique offers new ways to understand disease and develop genetic treatments for vascular disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bispecific Antibodies Targeting Different Epitopes on the HIV-1 Envelope Exhibit Broad and Potent Neutralization.

Journal of virology·2015
Same author

Methods for liposome-mediated gene transfer to the arterial wall.

Methods in molecular medicine·2014
Same author

Methods for liposome-mediated gene transfer to tumor cells in vivo.

Methods in molecular medicine·2014
Same author

Influenza virus h5 DNA vaccination is immunogenic by intramuscular and intradermal routes in humans.

Clinical and vaccine immunology : CVI·2012
Same author

Kruppel-like factor 2 (KLF2) regulates monocyte differentiation and functions in mBSA and IL-1β-induced arthritis.

Current molecular medicine·2012
Same author

Hematopoietic stem cells: transcriptional regulation, ex vivo expansion and clinical application.

Current molecular medicine·2011

Area of Science:

  • Molecular Biology
  • Cardiovascular Biology
  • Gene Expression and Regulation

Background:

  • Recent molecular biology advances enhance understanding of gene expression in mammalian cells.
  • This knowledge is now applied to cardiovascular system research.
  • Gene transfer is a key tool for studying gene function and regulation.

Purpose of the Study:

  • To review gene transfer methods for cardiovascular research.
  • To explore gene transfer's role in understanding vascular disease pathophysiology.
  • To discuss the potential of gene transfer for novel genetic treatments.

Main Methods:

  • Introduction of recombinant genes into host somatic cells.
  • Utilizing gene transfer to identify regulatory sequences.
  • Employing gene transfer in animal models for in vivo studies.

Main Results:

  • Gene transfer facilitates the study of gene structure and function.
  • It allows for the creation of animal models for human diseases.
  • Gene transfer aids in investigating gene function within intact animals.

Conclusions:

  • Gene transfer is an emerging approach for cardiovascular disease research.
  • It provides insights into vascular disease pathophysiology.
  • Gene transfer holds promise for developing genetic therapies for vascular disorders.

Related Experiment Videos