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Related Experiment Videos

Single breath diffusing capacity for carbon monoxide in stable asthma

P Collard1, B Njinou, B Nejadnik

  • 1Pulmonary Division, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Chest
|May 1, 1994
PubMed
Summary
This summary is machine-generated.

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In patients with asthma, single breath diffusing capacity for carbon monoxide (Dco) is normal or high, potentially due to improved lung apex perfusion. This finding may aid in diagnosing undiagnosed asthma.

Area of Science:

  • Pulmonary physiology
  • Respiratory medicine
  • Gas exchange assessment

Background:

  • Single breath diffusing capacity for carbon monoxide (Dco) assesses pulmonary gas exchange.
  • Previous studies on Dco in asthma have shown conflicting results.

Purpose of the Study:

  • To investigate Dco in patients with asthma.
  • To identify factors influencing Dco in asthma patients.

Main Methods:

  • Prospective measurement of Dco in 80 non-smoking asthma patients.
  • Radionuclide lung perfusion scans (133Xe) in 10 asthmatics and 10 controls.

Main Results:

  • Mean Dco was elevated at 117% of predicted values; transfer coefficient (D/VA) was 116% of predicted.

Related Experiment Videos

  • No correlation between Dco and atopy, asthma duration, or spirometry.
  • Asthmatics showed better upper lung zone perfusion compared to controls; Dco correlated positively with apex-to-base perfusion ratio (r=0.975).

    • Conclusions:

    • Dco is normal or elevated in uncomplicated asthma.
    • Elevated Dco may be linked to enhanced apical lung perfusion, possibly due to increased pulmonary arterial pressure or negative pleural pressure from bronchial narrowing.
    • High Dco suggests considering asthma in undiagnosed patients.