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Colon carcinoid tumors. A population-based study

C Spread¹, H Berkel, L Jewell

¹Department of Surgery, University Hospital, University of Alberta, Edmonton, Canada.

Diseases of the Colon and Rectum

|May 1, 1994

Summary

This summary is machine-generated.

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Colon carcinoid tumors are rare, diagnosed late, and have a poor prognosis. Key prognostic factors include tumor stage, histologic pattern, differentiation, nuclear grade, and mitotic rate.

Area of Science:

Gastroenterology
Oncology
Pathology

Background:

Carcinoid tumors, a type of neuroendocrine tumor, can occur in the colon.
Clinical presentation, survival rates, and prognostic factors for colon carcinoids are not well-established due to their rarity.

Purpose of the Study:

To evaluate the clinical presentation of patients diagnosed with colon carcinoid tumors.
To estimate survival rates and identify potential prognostic factors for this rare malignancy.

Main Methods:

A population-based study analyzed data from the Alberta Cancer Registry (1964-1988).
Clinical records and pathological materials of eligible patients were reviewed.
Survival was estimated using crude survival and Kaplan-Meier methods.

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Main Results:

36 colon carcinoid tumors were diagnosed; ileocecal and rectal carcinoids were excluded.
Average age at diagnosis was 68.4 years; 64% were Stage D and 22% Stage C at diagnosis.
Two-year and five-year survival rates were 34% and 26%, respectively, significantly lower than rectal/appendix carcinoids or colon adenocarcinomas.
Tumor stage, histologic pattern, differentiation, nuclear grade, and mitotic rate significantly influenced survival.

Conclusions:

Colon carcinoid tumors are rare, often diagnosed at advanced stages, and associated with a poor prognosis.
Prognostic indicators include tumor stage, histologic pattern, differentiation, nuclear grade, and mitotic rate.