Related Experiment Videos
Nicotine's opioid and anti-opioid interactions: proposed role in smoking behavior
1Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0613.
European Journal of Pharmacology
|December 1, 1993
Abstract:
Nicotine produced antinociception in mice which was antagonized noncompetitively by naloxone. In addition, at significantly lower doses, nicotine noncompetitively antagonized morphine-induced antinociception. A speculative suggestion regarding the opiatergic and anti-opiatergic actions of nicotine is that it significantly promotes and maintains smoking behavior.