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Cerebrospinal fluid production during proximal aortic cross-clamping
T Strømholm1, O D Saether, P Aadahl
1Department of Surgery, University Hospital of Trondheim, Norway.
European Journal of Vascular Surgery
|March 1, 1994
Summary
Thoracic aorta cross-clamping significantly increases cerebrospinal fluid pressure (CSFP). However, this study found no change in cerebrospinal fluid (CSF) production, suggesting other mechanisms are responsible for elevated CSFP during aortic XC.
Area of Science:
- Neurosurgery
- Cardiovascular Surgery
- Physiology
Background:
- Thoracic aorta cross-clamping (XC) is associated with increased cerebrospinal fluid pressure (CSFP).
- The underlying mechanism for this CSFP elevation remains unclear.
- Increased cerebrospinal fluid (CSF) production has been proposed as a potential cause.
Purpose of the Study:
- To investigate the effect of proximal thoracic aorta XC on CSF production rate.
- To determine if altered CSF production contributes to CSFP increase during XC.
Main Methods:
- Utilized the ventriculocisternal perfusion method with [14C] inulin in a porcine model.
- Measured CSF production rate before, during, and after 30 minutes of thoracic aorta XC.
- Monitored CSFP via a lateral ventricle catheter.
Main Results:
- CSFP increased significantly from 5 mmHg to 11 mmHg during thoracic aorta XC (p < 0.001).
- The CSF production rate remained unchanged, measuring 0.09 ml/min prior to XC and showing no significant alteration post-XC.
- Elevated CSFP persisted throughout the XC period.
Conclusions:
- Increased CSF production is not the cause of elevated CSFP during thoracic aorta XC.
- The findings suggest that other physiological mechanisms are responsible for the observed increase in CSFP during aortic XC.