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Acute renal failure after intravenous immunoglobulin therapy
A M Pasatiempo1, J A Kroser, M Rudnick
1Department of Medicine, Medical College Hospital, Philadelphia, PA 19129.
The Journal of Rheumatology
|February 1, 1994
Abstract:
We describe 3 patients given intravenous immunoglobulin (IVIG) who developed acute renal failure temporally related to IVIG therapy. The rise in BUN and creatinine appeared to be transient and reversible 8-14 days after discontinuation of the drug. Renal dysfunction was mild in 2 patients but was severe in one who presented with azotemia, worsening congestive heart failure, severe hyponatremia, hyperkalemia, and metabolic acidosis necessitating hemodialysis. Renal dysfunction was not associated with a specific immunoglobulin preparation or dose.