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[Changes in the lipid profile in chronic hepatopathies]
J Perales1, M Angel Lasunción, A Cano
1Servicio de Medicina Interna, Hospital Ramón y Cajal, Madrid.
Medicina Clinica
|March 19, 1994
Summary
Chronic liver disease alters lipoprotein and apolipoprotein patterns. Severe disease decreases hepatic lipoproteins, while biliary cirrhosis shows distinct lipid profiles and lipoprotein X, indicating cholestasis.
Area of Science:
- Biochemistry
- Clinical Chemistry
- Hepatology
Background:
- Lipoprotein and apolipoprotein patterns are altered in chronic liver disease.
- Analysis of these patterns relates to disease stage and cholestasis presence.
Purpose of the Study:
- To investigate lipoprotein and apolipoprotein differences in chronic liver disease.
- To correlate these differences with disease severity and cholestasis.
Main Methods:
- Studied 21 hepatic cirrhosis and 12 primary biliary cirrhosis patients.
- Separated plasma lipoproteins via ultracentrifugation; determined lipid and apolipoprotein composition.
- Identified Lipoprotein X using agarose gel electrophoresis.
Main Results:
- Minimal changes in early disease; severe hepatic cirrhosis showed decreased lipoproteins (VLDL, HDL) and absent Apo E in VLDL.
- Severe biliary cirrhosis exhibited high cholesterol, triglycerides, LDL, and decreased HDL; Lipoprotein X was detected.
- Distinct apolipoprotein compositions of VLDL were observed across different hepatic diseases.
Conclusions:
- Severe chronic liver disease reduces hepatic lipoproteins, likely due to synthesis defects.
- Biliary cirrhosis shows a cholestasis pattern with Lipoprotein X, increased free cholesterol, decreased HDL, and VLDL rich in Apo C-II.
- Lipoprotein and apolipoprotein profiles differ significantly based on the type and severity of hepatic disease.