Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Therapeutic aerosol: principles and practices

B M Zainudin1

  • 1Department of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur.

The Medical Journal of Malaysia
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bronchodilator response to inhaled beta-2 agonist and anticholinergic drugs in patients with bronchiectasis.

Respirology (Carlton, Vic.)·1999
Same author

Addition of inhaled salmeterol to inhaled corticosteroids in patients with poorly controlled nocturnal asthma.

Respirology (Carlton, Vic.)·1999
Same author

A report of the first three cases of diffuse panbronchiolitis in Malaysia.

The Medical journal of Malaysia·1996
Same author

Clinical patterns of X linked agammaglobulinemia in Malaysian children.

Acta paediatrica Japonica : Overseas edition·1995
Same author

Causative organisms in acute exacerbation of chronic airways disease and response to ofloxacin therapy.

Drugs·1995
Same author

Idiopathic pulmonary haemosiderosis occurring in a Malaysian patient.

Singapore medical journal·1994
Same journal

Diagnostic performance of computed tomography colonography following incomplete colonoscopy and its associated factors: A single-centre retrospective study.

The Medical journal of Malaysia·2026
Same journal

Gender representation across surgical specialties in Malaysia.

The Medical journal of Malaysia·2026
Same journal

Non-specific orbital inflammation: Clinical and histopathological insights from a 6-year single-centre Malaysian cohort.

The Medical journal of Malaysia·2026
Same journal

Prevalence of metabolic associated fatty liver disease (MAFLD) and its associated factors among type 2 diabetes mellitus (T2DM) in primary care settings in Kuantan, Pahang.

The Medical journal of Malaysia·2026
Same journal

Sixteen years of cochlear implant surgery in cochleovestibular malformation and cochlear nerve deficiency: Insights from northern Malaysia.

The Medical journal of Malaysia·2026
Same journal

Evaluation of vision-related quality of life and its associated factors in patients with diabetic vitreoretinal disease post trans pars plana vitrectomy using visual functioning questionnaire-25.

The Medical journal of Malaysia·2026
See all related articles

Optimizing aerosol drug delivery to the lungs, particularly the peripheral airways, enhances treatment efficacy and minimizes side effects. Proper inhalation technique and device selection, such as spacers or breath-actuated inhalers, are crucial for effective drug deposition.

Area of Science:

  • Pulmonary drug delivery
  • Respiratory medicine
  • Pharmaceutical sciences

Background:

  • Direct drug delivery via aerosols offers advantages over oral administration, including lower dosage, faster onset, and reduced systemic side effects.
  • Airway anatomy presents challenges for inhaled particles, necessitating optimal inhalation techniques for effective peripheral airway targeting.
  • Pressurized metered-dose inhalers (pMDIs) can lead to significant throat impaction due to high propellant pressure, reducing the amount of drug reaching the lungs.

Purpose of the Study:

  • To review the principles of optimal aerosol inhalation for effective drug delivery to the peripheral airways.
  • To discuss strategies and devices that improve inhaled drug deposition and overcome limitations of standard inhaler use.
  • To highlight the importance of coordinated actuation and inhalation for maximizing therapeutic benefit.

Related Experiment Videos

Main Methods:

  • Review of existing literature on aerosol drug delivery principles and devices.
  • Analysis of factors influencing inhaled particle deposition in the respiratory tract.
  • Evaluation of the efficacy of different aerosol delivery systems, including pMDIs, spacers, dry powder inhalers, and nebulizers.

Main Results:

  • Optimal aerosol delivery requires small particle size and coordinated inhalation, especially with pMDIs.
  • Spacers can mitigate poor coordination and reduce throat impaction, improving drug delivery.
  • Breath-actuated dry powder inhalers and properly used nebulizers offer alternative effective aerosol delivery methods.

Conclusions:

  • Effective aerosol drug delivery to the peripheral airways is achievable with appropriate techniques and devices.
  • Patient education on inhalation technique and device selection is critical for optimizing therapeutic outcomes.
  • Technological advancements in inhaler design continue to improve the efficiency and safety of aerosolized medications.