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Related Experiment Videos

Behavioral evaluations in developmental toxicity testing: MARTA survey results

E A Lochry1, C Johnson, P J Wier

  • 1Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, NJ 08903-0191.

Neurotoxicology and Teratology
|January 1, 1994
PubMed
Summary

A 1991 survey revealed standardized behavioral testing in Good Laboratory Practice (GLP) developmental toxicity studies. Behavioral assessments are now common in pharmaceutical safety evaluations.

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Area of Science:

  • Toxicology
  • Neuroscience
  • Pharmacology

Background:

  • Behavioral evaluations are crucial for assessing developmental toxicity.
  • The Middle Atlantic Reproduction and Teratology Association (MARTA) surveyed laboratories in 1991.
  • The survey aimed to identify industry standards for behavioral test batteries in GLP studies.

Purpose of the Study:

  • To determine the extent of an "industry standard" for behavioral test batteries.
  • To assess the common methodologies used in GLP developmental toxicity studies.
  • To track the integration of behavioral assessments in pharmaceutical safety testing.

Main Methods:

  • A survey was conducted among laboratories performing behavioral evaluations.
  • Data collected focused on commonly used developmental, reflexive, and learning parameters.

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  • Specific tests included physical and reflexive landmarks, locomotor activity, learning/retention tests, and startle paradigms.

    • Main Results:

    • High similarity in methodologies was observed across laboratories.
    • Locomotor activity was utilized by 80% of labs.
    • 76% of labs performed learning/retention evaluations, with watermaze and passive avoidance being most common.
    • Automated startle paradigms were used by 28% of labs.
    • A progressive increase in GLP studies incorporating behavioral assessments was noted.

    Conclusions:

    • Behavioral tests have become an established component of developmental toxicity assessments.
    • Standardization in behavioral testing methodologies facilitates reliable pharmaceutical safety evaluations.
    • The findings highlight the growing importance of behavioral endpoints in regulatory toxicology.