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Deoxyspergualin--a novel immunosuppressant
R M Jindal1, M A Tepper, K Soltys
1Transplantation Services, University Hospital, Boston, MA.
The Mount Sinai Journal of Medicine, New York
|January 1, 1994
Abstract:
DSG appears to have a unique, although as yet undefined, mechanism of action and may be a useful immunosuppressive agent. Because DSG is effective in reducing preformed antibodies in the xenograft situation, it may have a significant advantage in ABO-incompatible grafts in transplant recipients with high panel-reactive antibodies. Most important, DSG may have a definitive role in immunosuppressive therapy for pancreatic grafts.