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Wilson's disease: MRI with clinical correlation

A C Magalhaes1, P Caramelli, J R Menezes

  • 1Department of Radiology, Hospital das Clinicas, University of Sao Paulo, Brazil.

Neuroradiology
|January 1, 1994
PubMed
Summary

Magnetic resonance imaging (MRI) reveals correlations between clinical symptoms and brain changes in Wilson's disease patients. Specific MRI findings, like putaminal lesions, link to neurological symptoms such as dystonia and Parkinsonism.

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Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Wilson's disease is a genetic disorder causing copper accumulation in organs, particularly the brain.
  • Neurological and psychiatric symptoms are common, but their correlation with imaging findings requires further elucidation.

Purpose of the Study:

  • To investigate the relationship between clinical presentation and Magnetic Resonance Imaging (MRI) findings in Wilson's disease patients.
  • To identify specific MRI markers associated with neurological deficits in Wilson's disease.

Main Methods:

  • Eleven patients with Wilson's disease underwent MRI on a 1.5 T system.
  • Clinical data, including symptom severity and duration, were collected and correlated with MRI results.

Main Results:

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  • Symptomatic patients showed abnormalities in five or more brain sites on MRI.
  • The putamen was affected in all symptomatic patients, with peripheral high signal lesions on T2-weighted images noted.
  • Lesions in the corpus striatum or substantia nigra correlated with Parkinsonian features in five patients.

Conclusions:

  • MRI is an effective tool for assessing central nervous system involvement in Wilson's disease.
  • Specific MRI findings demonstrate anatomoclinical correlations, aiding in understanding disease progression and symptom manifestation.