[Morphofunctional status of tissue basophils in cytostatic disease]

A single administration of cyclophosphamide in the maximally tolerable dose results in an increase in the counts of mesenterial, peritoneal, and dermal mast cells in mice, by modifying their morphological characteristics and enhancing their functional activity. This effect becomes apparent on days 2-7 of the drug injection. In the late periods after cyclophosphamide, the morphological changes in tissue basophils are less profound; their functional activity remains rather high during 3 months. Morphofunctional changes in mast cells and the results of intradermal allergic tests suggest that there is a developing predisposition to allergic reactions under the action of the cytostatic.